Cosmetics 2024, 11(4), 108

Yang, T., Chen, L., & Huang, X.

"Examining How Diet and Lifestyle Influence Skin Appearance through a Common Risk Factor: Excess Iron—A Comprehensive Review"

J. Invest. Dermal. 2003, 121: 177-183.

Pelle E., Huang, X., Mammone, T., Marenus, K., Maes, D., and Frenkel, K.

“UVB-induced oxidative DNA base damage in normal human epidermal keratinocytes.”

Dermascope, Sept. 2023, 81.

Huang, X.

“Aging is rusting – Addressing the causes of aging.”

Breast, 2008, 17: 172-179.

Dai, J. S., Bosland, M., Bernhardt. G., Frenkel, K., and Huang, X.

“Role of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status.”

Lancet Oncol., 2008,. 9: 803-807.

Huang, X.*

“Does iron have a role in breast cancer?”

J. Invest. Dermat. 2008, 128: 1280-1285.

Pell, E., McCarthy, J., Seltmann, H., Huang, X., Mammone, T., Zouboulis, C. C., and Maes, D.

“Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes.”

Antioxid. Redox Signal., 2009, 11, 2939-2943.

Jian, J.L., Pelle, E., and Huang, X.

“Iron and Menopause: Does increased iron play a role in menopause-related osteoporosis and skin aging?” Article reported by Obesity, Fitness & Wellness Week, OBGYN & Reproduction Week, and Women's Health Weekly

Exp. Dermatol. 2011, 20: 249-254.

Jian, J.L., Pelle, E., Yang, Q., Pernodet, N., Maes, D., and Huang, X.

“Iron sensitizes keratinocytes and fibroblasts to UVA-mediated matrix metalloproteinase-1 through TNF-α and ERK activation."

Contraception, 2011, 84: 285-290.

Friedman, J., Cremer, M., Qurat ul-ain, J., Huang, X., Jian, J. Shah, S. and Katz S.D.

“Oral contraceptive use, iron stores, and vascular endothelial function in healthy women.”

Photodermatol, Photoimmunol & Photomed, 2011, 27: 231-235.

Pelle, E., Jian, J., Declercq, L., Dong, K., Yang, Q, Pourzand, c., Pernodet, N., Maes, D., Yarosh, D.B., and Huang, X.

“Protection against UVA- and iron-induced oxidative damage in normal human epidermal keratinocytes by the use of a caged-iron chelator.”

J. Cosmetic Sci. 2012, 63: 359-364.

Pelle, E., Maes, D., Huang, X., Frenkel, K., Pernodet, N., Yarosh, D.B., Zhang, Q.

“Protection against UVB-induced oxidative stress in human skin cells and skin models by methionine sulfoxide reductase A.”

Annals Epidemiol. 2007, 17: 354-358.

Zeleniuch-Jacquotte, A., Shore, R.E., Zhang, Q., Dai, J.S., Karkoszka, J., Arslan, A.A., Koenig, K., Afanasyeva, Y., Frenkel, K., and Huang, X.

“Long-term reliability of serum assays of iron status in post-menopausal women.”

J. Bone Min. Res. 2011, 26: 1188-1196.

Yang, Q., Jian, J., Abramson, S.B., and Huang, X.

“Inhibitory effects of iron on bone morphogenetic protein-2-induced osteoblastogenesis.”

Endocrinology, 2012, 153, 3170-3178. Article Featured by News and Views, Endocrinology 153: 2942-4, 2012.

Yang, Q., Jian, J., Katz, S.D., and Huang, X.

“Estrogen inhibits hepcidin through an estrogen responsive element half site.”

Cancer Epidemiol. Biomarl. Prev. 2012, 21, 859-865. 

Siegel, E.M., Patel, N., Lu, B., Lee,  J.H., Nyitray, A.G., Huang, X., Villa, L.L., Franco, E.L.,  and Anna R. Giuliano, A.R.

“Circulating Biomarkers of Iron Storage and Clearance of Incidence Human Papillomavirus Infection.”

Chem. Res. Toxicol. 1993, 6: 452-458.

Huang X., Laurent P.A., Zalma R., and Pezerat H.

"Inactivation of alpha-1 antitrypsin by some aqueous coal solutions. Possible relation to the emphysema."

Chem. Res. Toxicol. 1994, 7: 451-457.

Huang X., Zalma R., and Pezerat H.

"Factors that influence the formation and stabilization of FeSO4 in coal dust. Possible relation to the emphysema of coal workers."

Chem. Res. Toxicol., 1998, 11: 722-729.

Huang, X., Fournier, J., Koenig, K., and Chen, L. C.

“Buffering capacity of coal and its acid soluble Fe2+ content: Possible role in coal workers’ pneumoconiosis.”

Free Rad. Res. 1999, 30: 439-452.

Huang, X., Zalma, R., and Pezerat, H.

“Chemical reactivity of the carbon-centered free radicals and ferrous iron in coals: role of bioavailable Fe2+ in coal workers’ pneumoconiosis.”

J. Biosci. 2003, 28: 95-100.

Zhang, Q. and Huang, X.

"Induction of interleukin-6 by coals containing bioavailable iron is through both hydroxyl radical and ferryl species."

Toxicol. Appl. Pharmacol. 2003, 191: 40-47.

Huang, X., and Zhang, Q.

“Coal-induced AP-1 is required for IL-6 gene expression: Mediation through ERKs and p38 MAPK Pathways.”

Am. J. Ind. Med. 2002, 42: 171-179

Zhang, Q., and Huang, X.

“Induction of ferritin and lipid peroxidation by coal samples with different prevalence of coal workers’ pneumoconiosis: Role of iron in the coals.”

Am. J. Respir. Cell Mol. Biol. 2002, 27: 568-574.

Huang, C., Li, J., Zhang, Q., and Huang, X.

“Role of bioavailable iron in coal dust-induced activator protein-1 and nuclear factor of activated T cells activation: Difference between the Pennsylvania and Utah coal dusts.”

Environ. Health Perspect. 2005, 113: 964-968.

Huang X. Li, W. and Finkelman, R. B.

“Mapping and prediction of coal workers’ pneumoconiosis with bioavailable iron content in the coals.”

Mutation Res. 2003, 533: 153-171.

Huang X.

“Iron overload and its association with cancer risk in human: Evidence for iron as a carcinogenic metal.”

Chapter 17, In Handbook on the Toxicology of the Metals, Volume II (Editors: Nordberg, G., and Costa, M.), 5th Edition, 2021, pp. 391-417.

Tenenbein, M and Huang, X.

“Iron”

French Agricultural Letters (for publication in China), 1990, 5: 27 – 32.

Huang X., Dazy A.C. and Pichon Y.

"A rapid method of electrophysiologic evaluation of molecular toxicity in an animal model and an algae model"

French Agricultural Letters (for publication in China), 1991, 6: 4 - 5.

Huang X.

"Development of toxicology and legislation"

Toxicol. Appl. Pharmocol. 1993, 120: 29-36.

Huang X., Frenkel K., Klein C. B., and Costa M.

"Nickel induces increased oxidants in intact mammalian cells as detected by dichlorofluorescein fluorescence."

Environ. Health Perspect. 1994, 102: 281-284.

Huang X., Zhuang Z. X., Frenkel K., Klein C. B., and Costa M.

"The role of nickel (II) and nickel-mediated reactive oxygen species in the mechanism of nickel carcinogenesis."

Carcinogenesis. 1994, 15: 545-548.

Huang X., Klein C. B., and Costa, M.

"Ni3S2 specifically enhances the formation of oxidants in the nuclei of CHO cells as detected by dichlorofluorescein."

Toxicol. Appl. Pharmacol. 1994, 126: 319-325.

Zhuang Z. X., Huang X., and Costa M.

"Nickel increases oxidants resulting in protein oxidation and amino acid-DNA cross-linking in intact cultured cells."

Cancer Res. 1995, 54: 6407-12. 

Salnikow, K., Gao, M., Voitkun, V., Huang, X., and Costa, M.

"Alterations in response to oxidative stress in nickel resistant mammalian cells."

Carcinogenesis 1995, 16: 1753-1759.

Huang, X., Kitahara, J., Zhiktovich, A., Dowjat, K., and Costa, M.

“Heterochromatic proteins specifically enhance nickel-induced 8-oxo-dG formation.”

Appl. Occup. Ind. Hyg J. 1996, 11 (7): 973-979.

Chen, L. C., Huang X., Wu, C. Y., Zalma, R., Pezerat, H., and Qu Q. S.

“The role of FeSO4 in coal dust induced lung injury.”

Biometals 1996, 9: 151-156.

Dowjat, K., Huang, X., Costentino S., and Costa, M.

“Underexpression of a peroxidase gene in Ni-transformed cells results in their resistance to killing by peroxides.”

Free Rad. Biol. Med. 2001, 31: 1341-1351.

Huang, X., Powell, J., Mooney, L.A., C. Li, and Frenkel, K.

“Importance of complete DNA digestion in minimizing variability of 8-oxo-dG analysis.”

Free Rad. Biol. Med. 2002, 32: 84-92.

Huang, X., Dai, J. S., Fournier, J., Ali, A. M., Zhang, Q., and Frenkel, K.

“Ferrous ion autoxidation and its chelation in iron loaded human liver HepG2 cells."

Free Radic. Res., 2002, 36: 285-294.

Zhang, Q., Dai, J. S., Ali, A. M., Chen, L. C., and Huang, X.

“Roles of bioavailable iron and calcium in coal-dust-induced oxidative stress: Possible implications in coal workers’ lung disease.”

Biometals, 2003, 16: 285-293.

Ali, A. M., Zhang, Q., Dai, J. S., and Huang, X.

“Calcein as a fluorescent iron chemosensor for the determination of low molecular weight iron in biological fluids.”

J. Toxicol. Environ. Health A, 2003, 66: 1249-1265.

Hu, W., Zhang, Q., Su, W. C., Feng, Z., Rom, W. N., Chen, L. C., Tang, M-s., and Huang, X.

“Gene expression of primary cultured normal human bronchial epithelial cells in response to coal dust with different prevalence of coal workers’ pneumoconiosis.”

J. Biosci. 2003, 28: 95-100.

Zhang, Q. and Huang, X.

"Induction of interleukin-6 by coals containing bioavailable iron is through both hydroxyl radical and ferryl species."

Toxicol. Appl. Pharmacol. 2003, 191: 40-47.

Huang, X., and Zhang, Q.

“Coal-induced AP-1 is required for IL-6 gene expression: Mediation through ERKs and p38 MAPK Pathways.”

Toxicology, 2004, 203: 199-209.

Dai, J. S., Huang, C., Wu. J., Yang, C. F., Frenkel, K., and Huang, X.

“Iron-induced interleukin-6 gene expression is mediated through the extracellular signal-related kinase and p38 mitogen-activated protein kinase pathways.”

Nutr. Cancer, 2004, 49 (2): 162-169.

Ilsley, J. N., Belinsky, G. S., Guda, K., Zhang, Q., Huang, X., Blumberg, J. B., Milbury, P.E., Roberts, L. J. II, Stevens, R. G., Rosenberg, D.W.

“Dietary iron promotes azoxymethane-induced colon tumors in mice.”

J. Toxicol. Environ. Health, 2005, 68: 1663-1679.

Zhang Q. and Huang, X.

“Addition of calcite reduces iron’s bioavailability in the Pennsylvania coals – Potential use of calcite for the prevention of coal workers’ lung injury.”

Toxicology, 2005, 213: 81-96.

Yang, C. F., Wu, J., Zhang, R., Zhang, P., Eckard, J., Yusuf, R., Huang, X., Rossman, T.G., and Frenkel, K.

“Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As—transformed cells”

Free Rad. Biol. Med. 2006, 40: 444-452.

Wu, J., Eckard, J., Chen, H. B., Costa, M., Frenkel, K., and Huang, X.

“Altered iron homeostasis involvement in arsenite-mediated cell transformation”

Toxicol. Appl. Pharmacol., 2006, 213: 245-255.

Li, Q., Chen, H., Huang, X., and Costa, M.

“Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1α) and HIF regulated genes.” 

Biomarkers, 2006, 11: 306-318.

Hu, Y., Zhou, Z., Xue, X., Li, X., Fu, J., Cohen, B., Melikian, A.A., Desai, M., Tang, M.-S., Huang, X., Roy, N., Sun, J., Pan, P., and Qu, Q.,

“Sensitive biomarker of polycyclic aromatic hydrocarbons (PAHs): Urinary 1-hydroxypyrene glucuronide in relation to smoking and low ambient levels of exposure.”

Free Rad. Res., 2007, 41: 1135-1142.

Huang, X., Dai J. S., Huang, C. S., Zhang, Q., O. Bhanot, and Pelle, E.

“Deferoxamine synergistically enhances iron-mediated AP-1 activation: A showcase of the interplay between extracellular-signal-regulated kinase and tyrosine phosphatase.”

Biometals, 2012, 25: 927-937.

Wu, J., Sowinska, A., Huang, X., Klein, C.B., Pelle, E., Frenkel, K.

"Impairment of antioxidant defenses as a contributor to arsenite-induced cell transformation."

Am. J. Ind. Med., 2013, 56: 292-299.

Aladdin, M., Jian, J., Yang, Q., Chen, L.C., Finkelman, R.B., and Huang, X.

“Laboratory studies of the impact of calcite on in vitro and in vivo effects of coal dust: A potential preventive agent for coal workers’ pneumoconiosis?”

Coal Age, 2013, 118: 54-56.

Huang, X., Luo, Y., Zhang, Z.L., Dong, S.N., Luxbacher, K.

“Researchers believe calcite holds a promise as a deterrent for black lung.”

J. Xi’an Univ. Sci. Tech., 2014, 34: 761-768. 

Luo, Y. and Huang, X.

“Feasibility study to use calcite in mitigating black lung problems in Appalachian coal fields.”

Cancer Detect. Prevent. 2003, 27: 116-121.

Ali, M. A., Akhmedkhanov, A., Zeleniuch-Jaquotte, A., Toniolo, P., Frenkel, K., and Huang, X.

“Reproducibility of serum iron, ferritin, and nitrite: association with risk of renal cancer in women.”

Kidney Int. 2006, 69: 679-684.

Zheng, H. Y., Huang, X., Zhang, Q., and Katz, S. D.,

“Effect of iron sucrose on homocysteine-induced endothelial function in normal subjects.”

Blood Cells, Mol. Dis., 2008, 41:265-269.

Huang, X., Fung, E.T., Yip, C., and Zeleniuch-Jacquotte, A.

“Serum hepcidin is associated with soluble transferrin receptor-1 but not ferritin in healthy post-menopausal women.”

Cancer Cell Int., 2010, 10: 28. Highly accessed on the Publisher’s website with more than 2,000 downloads since its publication in August 2010.

Eckard, J., Dai, J., Wu, J., Jian, J.L., Yang, Q., Frenkel, K., Chen, H., Costa, M., and Huang, X.

“Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis.”

Free Rad. Biol. Med. 2011, 50: 841-847.

Jian J, Yang Q, Dai J, Eckard J, Axelrod D, Smith J, and Huang X.

“Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer."

J. Biol. Chem. 2011, 286, 35708-15.

Jian, J., Yang, Q., and Huang, X.

"Src regulates Tyr20 phosphorylation of transferrin receptor-1 and promotes breast cancer cell survival."

BMC Musculoskeletal Disorders, 2014,15, 8.

Kennish, L., Attur, M., Oh, C., Krasnokutsky, S., Samuels, J., Huang, X. and Abramson, S.B.

“Age- and HFE C282Y mutation-dependent ferritin increase as a predictor of knee osteoarthritis development.”

Calcif. Tissue Int. 2014, 94: 632-639.

Shen, G.S., Yang, Q., Jian, J.L., Zhao, G. Y., Liu, L.L., Wang, X., Zhang, W., Huang, X., Xu, X. J.

“Hepcidin knockout mice display defects in bone microarchitecture and changes of bone formation markers.”

J. Endocrinol. 2015, 226: 121-134.

Fei, B.B., Shen, G.S., Jiang, Y., Zhang, W., Huang, X., Xu, Y.J.

“Iron overload increases osteoclastogenesis and aggravates the effects of ovariectomy on bone mass.”

Horm Cancer, 2019, 10(2-3): 77-88.

Ozten, N., Vega, K., Liehr, J., Huang, X., Horton, L., Cavalieri, E., Rogan, E.G., Bosland, M.C.

“Role of estrogen in androgen-induced prostate carcinogenesis in NBL rats.”

(Eds. Sun B. Q., Cao M. Q), Beijing Agricultural University Press, Beijing, 1993, pp. 37-55.

Huang X., Xiao X. G., Shi J. N. et al.

"General aspect of French agricultural education." In "Modern French Agriculture"

Sci. Total  Environ. 1994, 148: 191-199.

Costa M., Zhuang Z. X., Huang X., Costentino S., Klein C. B., and Salnikow K.

“Molecular mechanism of nickel carcinogenesis.”

Environ. Health Perspect. 1994, 102: 127-130.

Costa M., Costentino S., Salnikow K., Huang X., and Zhuang Z. X.

"Molecular mechanism of nickel carcinogenesis."

In Medical Mineralogy and Geochemistry (Editors: Schoonen M., and Niati, N.), 2006, vol. 64: 153-172. 

Huang, X., Gordon, T., Rom, W. N., and Finkelman, R. B.

“Interaction of iron and calcium minerals in coals and their roles in coal dust-induced occupational lung diseases.”

J. Toxicol. Environ. Health, Part B, 2008, 11: 45-67. 

Huang, X., and Finkelman R. B.

“Understanding the chemistry of macerals and minerals in coal dusts and its potential application for occupational lung disease prevention.”

Am. J. Biomed. Sci., 2011, 3: 95-106.

Huang, X.

“Iron, oxidative stress, and cell signaling in the pathogenesis of coal workers’ pneumoconiosis, silicosis, and asbestosis.”

Chin. J. Osteoporosis & Bone Miner. Res., 2012, 5: 1-6.

Xu, Y. J., and Huang X.

“Decreasing iron overload: A new approach for prevention and treatment of postmenopausal osteoporosis.”

BMC Cancer, 2013, 13, 307.

Jian, J., Yang, Q., Shao, Y., Axelrod, D., Smith, J., Singh, B., Krauter, S., Chiriboga, L., Yang, Z., Li, J. and Huang, X.

“A link between premenopausal iron deficiency and breast cancer.”

April 2013, Coal Age, April issue, page 54-56.

Huang, X., Luo, Y. Zhang, Z. L., Dong, S.N., and Luxbacher, K.

“Increased prevalence of coal workers’ pneumoconiosis: What should we do now?”

Bone, 2013, 55: 458-460.

Huang, X.,, Xu, Y.J., and Partridge, N.,

“Dancing with sex hormones, could iron contribute to gender differences in osteoporosis?”

Natl Med. J. China, 2013:, 93: 3809-3911.

Xu, Y. J., and Huang, X.

“Roles of iron and sex hormones in the gender differences of osteoporosis.”

Osteop. Int. 2012, 23: 2403-2408.

Li, G.F., Pan, Y.Z., Sirois, P., Li, K., and Xu, Y.J.

“Iron homeostasis in osteoporosis and its clinical implications.”

Exp. Therap. Med., 2015, 10: 7-11.

Chen, B., Li, G.F., Shen, Y., Huang, X., and Xu, Y.J.

“Reducing iron accumulation: A potential approach for the prevention and treatment of postmenopaual osteoporosis (Review)."

Am. J. Clin. Nutr., 2011, 94: 613-614.

Huang, X. and Katz, S.

“Intakes of dietary iron and heme-iron and risk of postmenopausal breast cancer in the National Institutes of Health-AARP Diet and Health Study.”

Mining Engineering, 2013, 67(2): 47-49.

Huang, X. Luo, Y., and Luxbacher, K.

“Comments on coal workers’ pneumoconiosis prevalence disparity between Australia and the United States.”

Thesis of the University of Paris VII, Defended in November, 1991.

Huang X.

"Properties of coal dust may play a role in the mechanisms of anthracosis, emphysema and gastric cancer"

(Ed. P. Sébastien) Colloque INSERM , 1991,  203 : 169-174.

Huang X., Zalma R. et Pezerat H.,

"Role of free radicals and redox reactions in the toxicity of coal dusts" In "Mechanisms in occupational lung diseases"