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Scientific History

More than 125 years of research shows that iron produces harmful free radicals that can contribute to a number of disease states as well as the visible signs of skin aging.


Iron promotes the formation of hydroxyl free radicals. Iron causes oxidative damage to proteins, lipids, and DNA in cells, Tissues and organs

L.R. Weintraub

Iron is excreted through skin exfoliation, making skin susceptible to oxidative damage

R.G. Stevens

Increased iron stores increase the risk of cancer

X. Huang

Bioavailable iron in mixed coal dusts is identified as an active compound in inducing black lung disease

C. Pourzand

Ultraviolet A (UVA) causes oxidation by degrading ferritin; UVA-mediated skin photoaging is caused by iron released from ferritin

X. Huang

Iron and UVA work together to enhance collagenase-1 activity, which leads to wrinkle formation and skin thinning

Results: The Rust is History. Your skin functions more youthfully.


i-On Age Disrupting Skincare with DII® Technology is the only cosmetic product dermatologist-approved and clinically proven to reduce visible lines and wrinkles, increase the appearance of elasticity, even skin tone, plump skin and hydrate more rapidly.

The results stand up to the most rigorous lab testing

In a 42-day clinical trial, an unprecedented 100% of women saw improvement across every measure in objective, subjective and biomechanical tests 

The Methods:
The Visual Grading Scale

Three trained clinical evaluators graded each study participant on an 11-point intensity grading scale for fine lines, wrinkles, brightness and firmness, and found statistically significant improvements in all evaluated skin parameters when compared to the baseline at every evaluation point.

Skin Hydration

Novameter readings, which use electroconducTvity to measure how much water is in the skin, demonstrated statistically significant increases in mean moisturization.

Firmness and Elasticity

Cutometer readings, in which succition is applied to the skin in order to measure the skin's resistance to suction (firmness) and its ability to return into its original state (elasticity), demostrated statistically significant improvement in both measures at each evaluation time point.

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