It unleashes emotions such as lust, confidence, courage, stamina, and resilience. It is considered to be the most ‘human’ metal and so, is distrusted by the ethereal entities and spirits.

The origin of iron’s chemical symbol Fe is from the Latin word ‘ferrum’ meaning iron.

We speak of Iron Masters. Iron Men. And Iron Ladies.

Iron is an essential mineral. Vital for the body’s health and development. A major component of hemoglobin. Without enough iron the body can’t make healthy oxygen carrying red blood cells.

Starting in adolescence, a woman's daily iron needs increase. Women need more iron because they lose blood each month during their period. 

However, too much of anything is a bad thing and too much iron can have detrimental effects - not just on your skin’s appearance – but on its overall health.

Pre-and-post-menopause, iron can accumulate in the skin by as much as 42%.

This overload leads to the production of free radicals that increase oxidative damage and accelerate the aging process.

Meet Dr. Xi Huang – Science’s Iron Man

It began with over 125 years of scientific research pointing to the negative impacts of excess iron on aging.

It spurred an intense curiosity that quickly became an obsession. And then inspired a deep sense of purpose.

Dr. Xi has devoted his career to studying the negative impacts of too much iron in the body. Upon further study in women, Dr. Xi found that following during and post menopause and the cessation of menstruation (an additional means of removing excess iron from the body), skin faces an increased challenge in the removal of excess iron. Dr. Xi investigated how these increased iron levels contribute to the manifestation of acceler­ated skin aging and photoaging after menopause as opposed to estrogen deficiency – commonly regarded as the main causative factor.

Research revealed that this iron overload is in fact the key driver of destructive free radicals that do the greatest damage to the skin.

While Cosmetic Science has long understood this concern, until now it has been inadequately addressed with no solution.

Dr. Xi’s dedication to ongoing research on the impact of excess iron has resulted in a breakthrough technology for a full range of differentiated “age disrupting” skincare products to finally solve the problem. Until now there has been no safe solution. FE:I Beauty Tech’s Patented De-Ironizing Inducer, known as DII®, is the solution.

Today, Dr. Xi’s ultimate mission is to help achieve the highest level of health for skin.

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More About Dr. Xi:

Dr. Xi’s early work—for which he earned master’s and PhD degrees in toxicology and applied pharmacology at the Université Paris VII—focused on environmental and occupational medicine in which he identified bioavailable iron in coals as a major active compound in black lung disease. It is in this work that Dr. Huang made the important discovery that calcite naturally found in certain coals, such as those from Utah and Colorado, inhibits the bioavailability of iron, resulting in lower incidence of black lung disease. This discovery of a compound able to safely inhibit the harmful effects of iron helped lead to the creation of DII® Technology.

In addition to leading FE:I Beauty Tech, Dr. Huang is an active participant in the research and innovation communities. He has been a reviewer for more than 30 peer-reviewed journals, including the Lancet, Proceedings of the National Academy of Science and Cancer Research. He also serves as the chief technology officer of Ex Vivo Dynamics, Inc., where he guides the development of a medical device that will improve blood transfusions

Forget birthdays.
Aging is not chronological.
It’s biological.

You can deny birthdays all you like, but that won’t stop them from happening. Counting them adds up to your chronological age.

While our birthdays are beyond our control and years will go by, today, advanced science suggests that skin’s biological aging can be disrupted. By improving how well it faces daily challenges. And intercepting and reversing free radical damage before it accumulates.

It’s not science fiction. Today it is scientific fact.


Welcome to the brave new world of biological aging. Biological Age is a molecular measure indicated by how well your cells function over time. Diet, exercise, sleep, stress, life habits and attitude all affect our biological age. As well as the cumulative effect of environmental exposure to UV, blue light and pollution, which trigger free radical formation and oxidative stress.

Here’s a hot flash you probably haven’t heard before.

One more factor that accelerates biological aging in women is menopause. Estrogen deficiency has long been the focus of menopausal conversations, research and interventions. And estrogen dips have long been recognized as the primary cause of the menopausal symptoms, such as hot flashes and insomnia.

But that’s not the whole story.

Whereas estrogen decreases by as much as 90% (according to NIH) because of the cessation of ovarian functions, it is not the only reason menopause is a time of extremes. Ovulation decline leads to an overload of the very element that makes us strong and resilient. 


And therein lies the unaddressed problem.

You see, while iron is crucial for our body’s healthy physiological functions, in excess it is extremely damaging. Our bodies naturally eliminate excess iron through menstruation and exfoliation. With the cessation of menstruation, we lose the natural ability to eliminate excess iron through monthly blood loss.

Iron overload as a result of the cessation of menstruation after menopause is possibly the most important single determinant of biological skin aging and photoaging

You’re not aging. You’re rusting.

Iron overload, when exposed to UV radiation, blue light, air pollutants and irritants from other sources, creates free radicals that cause oxidative stress. Oxidative stress begets skin-aging yellowing, dullness, dinginess, dark spots and discolorations. Much like rust on metal, iron’s reaction with oxygen causes oxidative stress to the skin. (If you’ve ever seen a rusty bicycle, you know the corrosive damage the environment has on metal.) 

The amount of ferritin (an iron storage protein) accumulated in the skin increases by as much as 42% during the 10-year transition period from pre-menopause to post-menopause.

Menopausal skin is more sensitive to environmental factors due to an overload of iron. This leads to an increase in wrinkles, discoloration, loss of elasticity, and other signs of aging.

Until now, skin’s best defense against this damage has been antioxidants. But, they only attempt to fight oxidative stress by neutralizing free radicals in the skin.

The radical new approach.

It’s been half a century since the Free Radical Theory first proposed that free radical reactions are the cause of the aging, damage and death of all living things.

Just to recap, free radicals are naturally-occurring, unstable extra electrons that seek out other extra electrons from healthy cells, damaging them and creating more free radicals in the process.

Over the years, skincare experts have been neutralizing skin-damaging free radicals with a laundry list of antioxidant ingredients. With only temporary success. You see, neutralizing only renders free radicals inactive…for a time. Every day, skin is repeatedly bombarded by UV radiation, air pollutants and irritants from a multitude of sources. This stop-start cycle may be good enough for young skin. But as you enter perimenopause then menopause and post menopause the skin’s ability to function efficiently is overwhelmed by the presence of free-radical unleashing iron.

It’s a vicious cycle. With little progress made. And once the damage is done, it’s an uphill battle just to get back to neutral. 

Get your skin out of neutral.

Now the world’s leading authority on iron and skin, Dr. Xi Huang, has developed i-On® Age Disrupting Skincare with DII® Technology, the only skincare today that actually stops the oxidative process before it starts by disrupting the formation of iron producing free radicals.

The rust is history.

i-On® Age Disrupting Skincare features patented, proprietary
DII® Technology to exclusively:


the iron to a form capable of exfoliation


the iron from ferritin, the iron binding protein in skin


the iron naturally before it can cause skin rusting


previous past damage


collagen, clarity, elasticity and tone to restore skin’s healthy appearance